PAT instrument vendors
Make your Raman, FBRM, PVM, or NIR instrument the sensing substrate for autonomous control — and pull through more probes per train.
Learn morePartners
Autonomy needs instruments, iron, and integrators.
Polymorra is the intelligence layer. The instruments, control systems, skids, and services around it belong to partners who have earned their place in the plant.
Built for the plants that make the world’s small molecules
- Branded pharma
- Generics
- CDMOs
- Fine chemicals
- Peptide APIs
- High-potency APIs
- Continuous plants
Programs
Four ways to partner
Each program has a defined technical path and commercial model.
Automation & DCS OEMs
Offer AI-driven crystallization and reaction control on top of your control platform without building the models yourself.
Learn moreCDMOs
Differentiate on faster tech transfer and repeatable quality across client routes, and resell the capability to your customers.
Learn moreSystem integrators
Deliver Polymorra deployments, tag mapping, and validation support as a service practice.
Learn moreAccelerated computing
An NVIDIA-accelerated stack, from the train to the fleet
Perception at the edge, reasoning in the cloud, and a reactor-and-crystallizer twin in between.
Stack
Jetson at the train
Plant-edge inference per reactor or crystallizer train: PVM crystal-image models, FBRM feature extraction, Raman and NIR soft sensors, anomaly and safety classifiers. [ASPIRATIONAL]
Stack
TensorRT + Holoscan
Low-latency perception and sensor-stream preprocessing for in-situ imaging and PAT spectra inside validated control windows.
Stack
Triton + NIM
Route-specific polymorph, impurity, particle-size, endpoint, and batch-reasoning models served with validated version locks and rollback.
Stack
Omniverse + Cosmos
Reactor-and-crystallizer twin plus synthesis of rare crystallization faults — oiling-out, fouling, seed drift, wrong-polymorph nucleation. [ASPIRATIONAL]
Stack
RAPIDS + cuOpt
Telemetry ETL at campaign scale, plus scheduling, solvent recovery, and crystallization-profile optimization.
Stack
NeMo + DGX
Fine-tuned chemistry-process and batch-record reasoning trained on de-identified design-partner data and chemist corrections. [ASPIRATIONAL]
NVIDIA
Built on accelerated computing
Polymorra runs plant-edge perception on Jetson-class hardware with TensorRT and Holoscan, serves reasoning models with Triton and NIM, and builds the reactor-and-crystallizer twin on Omniverse — deployable under NVIDIA AI Enterprise. [ASPIRATIONAL]
- Edge inference next to the crystallizer
- Twin and synthetic-fault generation for rare failure modes
- Enterprise-supported deployment inside your infrastructure
What partners get
A technical path, not a logo swap
Connector certification, joint reference architectures, engineering support during pilots, and co-selling into API sites where both of us already have credibility.
- Certified connector program and test harness
- Joint reference architecture documents
- Deal registration and co-selling motion
Integrations
Connects to the systems already running your plant
Polymorra reads and writes through the reactor DCS, PAT instruments, crystallizer and isolation skids, historians, and MES you already validated.
Reactor control & DCS
Emerson DeltaVSiemens PCS 7Honeywell ExperionOPC UAModbus/TCP
PAT & analytics
Mettler-Toledo FBRMPVM in-situ imagingReactIREndress+Hauser RamanNIRHPLC / XRPD imports
Isolation & drying
Nutsche filter-dryersCentrifugesAgitated dryersConical millsMicronizers
MES, historian & quality
Körber PAS-XEmerson SyncadeOSIsoft PILIMSeBR / QMS exports
Plant-edge console
One screen for the batch that is running right now
Supersaturation, particle size distribution, predicted polymorph, impurity trajectory, and the next control move — with the evidence behind each number.
Polymorra plant-edge console showing live supersaturation, particle size distribution, predicted polymorphic form, and impurity trajectory for a running crystallization, with the recommended next control move.
Trust & compliance
Validated for GMP manufacturing
Polymorra is engineered for regulated drug-substance production: grounded outputs, immutable audit trails, graduated autonomy, and validation documentation from day one.
21 CFR Part 11
Immutable, validated audit log for every agent perception, recommendation, and control action, with e-signature-ready review flows.
GMP / ICH Q7
Change control, validated model versioning, and deployment documentation designed for drug-substance manufacturing.
SOC 2
SOC 2 Type I in progress, Type II on the roadmap; SSO/RBAC, encryption in transit and at rest. [ASPIRATIONAL]
Route & IP protection
Per-tenant isolation of routes, recipes, spectra, and crystal images. No cross-tenant training. On-prem option.
Graduated autonomy
Shadow → assist → bounded auto-control. Every autonomy level is explicitly configured, bounded, and revocable.
Grounded outputs
Every recommendation cites the spectra, images, telemetry, SOP, or specification it was derived from.
Plant-edge first
Inference runs on-site so control loops survive network loss; cloud is for training, fleet, and analytics.
Human-in-the-loop
Chemist and QA checkpoints are first-class: approve, correct, or reject — and every correction trains the models.
Enterprise
Built for multi-site pharma and CDMO networks
Multi-site deployment, plant-edge fleet management, custom route and crystallization models, validation support, and on-prem or hybrid installation with NVIDIA AI Enterprise.
Fleet of plant edges
Manage models, autonomy levels, and versions across every train in every site from one control plane.
Validation package
Qualification documentation, model version locks, and change-control artifacts your quality unit can review.
Outcome-linked pricing
Enterprise agreements can tie a component of fees to polymorph consistency, yield, or reprocessing reduction.
Dedicated engineering
Solutions engineers who speak crystallization, PAT, and GMP — not just software.
FAQ
Frequently asked questions
Both — in a deliberate order. Polymorra starts in shadow mode (perceive only), moves to assist (recommend, chemist approves), then to bounded auto-control on qualified trains where setpoint moves stay inside validated control windows. Every level is configured per train and revocable.
Polymorra is built for GMP (ICH Q7) and 21 CFR Part 11: immutable audit trail, validated model version locks with rollback, change control, grounded and citable outputs, and human-in-the-loop checkpoints. We ship a validation package and support IQ/OQ/PQ activities with your quality unit.
API or OPC access to your reactor DCS, PAT instruments (Raman, FBRM, PVM, NIR), crystallizer and isolation skids, and MES or historian — plus a train with enough campaign volume for clear ROI.
No. Per-tenant isolation of routes, recipes, spectra, and crystal images is enforced at the data and model layer. Cross-site benchmarks are opt-in and de-identified.
A typical wedge pilot instruments one train, runs shadow mode over a baseline campaign, then moves to assist mode with a defined polymorph, yield, or reprocessing success metric agreed up front.
Perception and control inference run at the plant edge. Cloud handles training, fleet management, and analytics — losing it degrades reporting, not the batch.
Let us put your instrument in the loop.
Start with one crystallizer or reactor train. Prove polymorph, yield, and reprocessing ROI in a validation-friendly pilot. Then expand across the plant.