Pricing
A failed API campaign costs far more than the software that prevents it. Polymorra is priced per train, per plant, or as an enterprise agreement with outcome components.
Pricing
Pricing follows the value of the batch: per reactor or crystallizer train, per plant, or an enterprise agreement with outcome components.
Manufacturers validating ROI on the wedge workflow.
$13,000
per reactor or crystallizer train / month
Most popular
Scaling plants adopting the full autonomous loop.
$85,000
per plant / month
CDMOs and pharma networks standardizing on Polymorra.
Custom
land $600k – $7M ACV
Built for the plants that make the world’s small molecules
How it works
Almost every deployment starts as a single-train Line subscription on the workflow that hurts most. When the metric moves, expanding to Plant is a commercial change, not a re-implementation.
Compare
| Capability | Line | Plant | Enterprise |
|---|---|---|---|
| Trains covered | One | All in site | All sites |
| Agents included | One workflow | All seven | All seven + custom |
| Digital twin | — | Yes | Yes + custom routes |
| Part 11 audit trail | Yes | Yes | Yes |
| Fleet management | — | Site | Multi-site |
| Validation support | Templates | Guided | Dedicated |
| Support | Business hours | 24/7 | 24/7 + SLA |
| Deployment | Plant edge | Plant edge | On-prem / hybrid |
Plant-edge console
Supersaturation, particle size distribution, predicted polymorph, impurity trajectory, and the next control move — with the evidence behind each number.
Polymorra plant-edge console showing live supersaturation, particle size distribution, predicted polymorphic form, and impurity trajectory for a running crystallization, with the recommended next control move.
Enterprise
Multi-site deployment, plant-edge fleet management, custom route and crystallization models, validation support, and on-prem or hybrid installation with NVIDIA AI Enterprise.
Manage models, autonomy levels, and versions across every train in every site from one control plane.
Qualification documentation, model version locks, and change-control artifacts your quality unit can review.
Enterprise agreements can tie a component of fees to polymorph consistency, yield, or reprocessing reduction.
Solutions engineers who speak crystallization, PAT, and GMP — not just software.
Integrations
Polymorra reads and writes through the reactor DCS, PAT instruments, crystallizer and isolation skids, historians, and MES you already validated.
Trust & compliance
Polymorra is engineered for regulated drug-substance production: grounded outputs, immutable audit trails, graduated autonomy, and validation documentation from day one.
Immutable, validated audit log for every agent perception, recommendation, and control action, with e-signature-ready review flows.
Change control, validated model versioning, and deployment documentation designed for drug-substance manufacturing.
SOC 2 Type I in progress, Type II on the roadmap; SSO/RBAC, encryption in transit and at rest. [ASPIRATIONAL]
Per-tenant isolation of routes, recipes, spectra, and crystal images. No cross-tenant training. On-prem option.
Shadow → assist → bounded auto-control. Every autonomy level is explicitly configured, bounded, and revocable.
Every recommendation cites the spectra, images, telemetry, SOP, or specification it was derived from.
Inference runs on-site so control loops survive network loss; cloud is for training, fleet, and analytics.
Chemist and QA checkpoints are first-class: approve, correct, or reject — and every correction trains the models.
Voices from the plant
Composite quotes from design-partner discovery interviews. [PLACEHOLDER — to be replaced with named references post-pilot]
“The crystallization step is where our campaigns live or die. Seeing supersaturation, particle size, and predicted polymorph in one place — and having the profile adjust itself — is what we have wanted for twenty years.”
“We do not want another dashboard. We want the batch to come out right and the record to be reviewable by exception. That is the only pitch that gets past QA.”
“Tech transfer is our bottleneck. If the twin can predict the plant crystal from the lab crystal, that is worth more than the software costs.”
FAQ
No — a GMP plant deployment is never self-serve. We run a paid, scoped pilot on one train with an agreed success metric, which is the fastest honest way to find out whether Polymorra works on your route.
Number of trains, number of agents, PAT instrument coverage, deployment model (plant edge vs on-prem), validation support depth, and whether the agreement includes outcome-linked components.
Standard DCS, PAT, historian, and MES connectors are included. Bespoke connectors to unusual or legacy systems are scoped as a one-time engineering item.
Both — in a deliberate order. Polymorra starts in shadow mode (perceive only), moves to assist (recommend, chemist approves), then to bounded auto-control on qualified trains where setpoint moves stay inside validated control windows. Every level is configured per train and revocable.
Polymorra is built for GMP (ICH Q7) and 21 CFR Part 11: immutable audit trail, validated model version locks with rollback, change control, grounded and citable outputs, and human-in-the-loop checkpoints. We ship a validation package and support IQ/OQ/PQ activities with your quality unit.
API or OPC access to your reactor DCS, PAT instruments (Raman, FBRM, PVM, NIR), crystallizer and isolation skids, and MES or historian — plus a train with enough campaign volume for clear ROI.
No. Per-tenant isolation of routes, recipes, spectra, and crystal images is enforced at the data and model layer. Cross-site benchmarks are opt-in and de-identified.
Start with one crystallizer or reactor train. Prove polymorph, yield, and reprocessing ROI in a validation-friendly pilot. Then expand across the plant.